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They first set up an animal model - they established lymphomas in mice and demonstrated they could treat them with mustard agents.
The pharmacokinetics of numerous drugs, including many that are commonly administered to individuals with heart disease, are affected by amiodarone.
Beyond the lack of apparent benefit, a series of three meta-analyses reported that vitamin e supplementation is associated with an increased risk of death; one of the meta-analyses performed by the cochrane collaboration also found significantly increased mortality for the antioxidant vitamins a and beta-carotene.
But perhaps the easiest indicator of mania would be if a noticeably clinically depressed person becomes suddenly cheerful, optimistic, happy, and full of energy.
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